Table 6.
Comparison of Clinical and Optic Disc Characteristics at Baseline and 4-year Follow-up Among Participants with Incident Open Angle Glaucoma in the Los Angeles Latino Eye Study
| Baseline | Follow-up | P-value | |
|---|---|---|---|
| Clinical Characteristics | |||
| Age(yrs) | |||
| Mean±SD | 62.8±11.6 | 67.1±11.6 | |
| Median | 64.0 | 68.0 | |
| IOP(mmHg)* | |||
| Mean±SD | 16.5±5.1 | 16.2±5.2 | 0.82 |
| Median | 16.0 | 15.0 | |
| %IOP>21 mmHg* | 14(15.1) | 14(15.1) | 0.76 |
| Mean defect(dB) | |||
| Mean±SD | -5.2±7.2 | -5.8±6.9 | 0.002 |
| Median | -2.5 | -3.3 | |
| PSD(dB) | |||
| Mean±SD | 3.3±2.6 | 4.1±2.6 | 0.0006 |
| Median | 2.3 | 3.3 | |
| CCT(μm) | |||
| Mean±SD | 547.3±43.5 | 547.1±44.3 | 0.84 |
| Median | 543.5 | 539 | |
| Optic Disc Characteristics | |||
| HCDR | |||
| Mean±SD | 0.5±0.1 | 0.6±0.1 | <0.0001 |
| Median | 0.5 | 0.6 | |
| VCDR | |||
| Mean±SD | 0.5±0.1 | 0.7±0.1 | <0.0001 |
| Median | 0.5 | 0.7 | |
| HCDR>0.7[n(%)] | 1(1.1) | 14(16.1) | 0.002 |
| VCDR>0.7[n(%)] | 1(1.1) | 32(36.8) | <0.0001 |
| HCDR asymmetry of ≥0.3[n(%)] | 0 | 10(11.5) | - |
| VCDR asymmetry of ≥0.3[n(%)] | 0 | 16(18.4) | - |
| Disc/NFL hemorrhage [n(%)] | 1(1.1) | 2(2.3) | 0.56 |
| Peripapillary atrophy [n(%)] | 54(62.1) | 64(73.6) | 0.09 |
| Diffuse thinning of neural rim to disc margin [n(%)] | 0 | 7(8.0) | - |
| Notching of neural rim [n(%)] | 0 | 51(58.6) | - |
OHT: ocular hypertension; IOP: intraocular pressure; PSD: pattern standard deviation; CCT: central corneal thickness
*
Participants with treatment history of glaucoma are not included. This analysis was done on participants with first-eye incidence only.
HCDR: horizontal cup-disc ratio; VCDR: vertical cup-disc ratio; NFL: nerve fiber layer