Table 7.
Comparison of Clinical and Optic Disc Characteristics at Baseline and 4-year Follow-up Among Participants with Incident Ocular Hypertension in the Los Angeles Latino Eye Study
| Baseline | Follow-up | P-value | |
|---|---|---|---|
| Clinical Characteristics | |||
| Age(yrs) | |||
| Mean±SD | 58.0±10.7 | 62.3±10.2 | |
| Median | 58.0 | 62.0 | |
| IOP(mmHg)* | |||
| Mean±SD | 16.8±2.5 | 23.2±2.5 | <0.0001 |
| Median | 16.7 | 22.3 | |
| %IOP>21 mmHg | 0 | 92(74.2%)* | - |
| Mean Defect(dB) | |||
| Mean±SD | -2.6±4.9 | -2.3±4.8 | 0.73 |
| Median | -1.4 | -1.0 | |
| PSD(dB) | |||
| Mean±SD | 2.6±2.1 | 2.5±1.8 | 0.57 |
| Median | 1.9 | 1.8 | |
| CCT(μm) | |||
| Mean±SD | 563.4±29.5 | 558.2±31.2 | 0.002 |
| Median | 561 | 558 | |
| Optic Disc Characteristics | |||
| HCDR | |||
| Mean±SD | 0.4±0.1 | 0.4±0.5 | 0.38 |
| Median | 0.3 | 0.3 | |
| VCDR | |||
| Mean±SD | 0.3±0.1 | 0.3±0.1 | 0.73 |
| Median | 0.3 | 0.3 | |
| HCDR>0.7[n(%)] | 0 | 0 | - |
| VCDR>0.7[n(%)] | 0 | 0 | - |
| HCDR asymmetry of ≥0.3[n(°%)] | 0 | 0 | - |
| VCDR asymmetry of ≥0.3[n(%)] | 0 | 0 | - |
| Disc/NFL hemorrhage [n(%)] | 0 | 2(1.6) | - |
| Peripapillary atrophy [n(%)] | 42(33.9) | 75(60.5) | <0.0001 |
| Diffuse thinning of neural rim to disc margin [n(%)] | 0 | 0 | - |
| Notching of neural rim [n(%)] | 0 | 0 | - |
OHT: ocular hypertension; IOP: intraocular pressure; PSD: pattern standard deviation; CCT: central corneal thickness
*
Participants with treatment history of glaucoma are not included. This analysis was done on participants with first-eye incidence only.
HCDR: horizontal cup-disc ratio; VCDR: vertical cup-disc ratio; NFL: nerve fiber layer