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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Immunol. 2012 Jun 25;189(3):1406–1417. doi: 10.4049/jimmunol.1200120

FIGURE 3.

FIGURE 3

B cells from NR4S3 and NR4S4 subcongenic mouse strains exhibit decreased diabetogenic capacity. (A) T1D incidence was monitored for up to 23 weeks in cohorts of female NOD.Igµnull mice that were lethally irradiated (1100 rad) at 4–5 weeks of age and reconstituted with 3×106 SBM admixed with 7×106 purified splenic B cells from NOD (n=33), NR4 (n=30), NR4S1 (n=16), NR4S2 (n=13), NR4S3 (n=10) or NR4S4 (n=17) strains. *p<0.05, **p<0.01, compared to NOD B cell reconstituted group (log-rank analysis). (B) Graph comparing mean time of disease onset in diabetic NOD.Igµnull mice reconstituted with NOD (n=23), NR4 (n=11), NR4S3 (n=2) or NR4S4 (n=6) B cells. The p-values between groups are shown (Student’s t-test).