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5380390 and 2818500 inhibit PRMT1 methyltransferase activity. a) In vitro methylation of PRMT1 on Histone4 after incubation with 100μM of potential inhibitors. Densitometry is below. b) Chemical structures of top four inhibitor scaffolds (2806087, 5380390, 2818500, and 2811408) and two negative controls (2797621 and 2729237). c) In vitro methylation of PRMT1 on Histone4 after incubation with titration of potential inhibitors. Data is representative of three independent experiments.
