Table 3.

Comparison of Weight Change Groups with the 4.9% Reduction to 4.9% Gain Reference Group

	Unadjusted Analysis		Adjusted Analysis
Variable	WOMAC Function Regression coefficient (95% CI), p	WOMAC Pain Regression coefficient (95% CI), p	WOMAC Function Regression coefficient (95% CI), p	WOMAC Pain Regression coefficient (95% CI), p
Weight Change Category*
≥10% reduction	4.71 (1.97, 7.45), 0.001	0.96 (0.06, 1.86), 0.036	4.07 (1.49, 6.65), 0.002	0.90 (0.06, 1.74), 0.035
5% to 9.9% reduction	0.55 (−1.42, 2.53), 0.582	−0.10 (−0.74, 0.54), 0.760	0.01 (−1.87, 1.89), 0.991	−0.26 (−0.87, 0.35), 0.402
4.9% reduction to 4.9% gain	reference	reference	reference	reference
5% to 9.9% gain	0.44 (−1.68, 2.57), 0.682	0.31 (−0.37, 1.00), 0.371	1.08 (−0.91, 3.07), 0.288	0.50 (−0.14, 1.15), 0.128
≥10% gain	−4.45 (−7.98, −0.93), 0.013	−1.15 (−2.27, −0.03), 0.045	−5.36 (−8.74, −2.00), 0.002	−1.56 (−2.62, −0.49), 0.004
Baseline dependent	NA	NA	0.43 (0.36, 0.49), <0.001	0.49 (0.42, 0.56), <0.001
Female	NA	NA	−1.60 (−2.85, −0.35), 0.012	−0.39 (−0.80, 0.01), 0.058
Comorbidity (number)	NA	NA	−1.26 (−1.91, −0.61), <0.001	−0.33 (−0.55, −0.12), 0.002
Depressed (yes)	NA	NA	−2.02 (−3.73, −0.31), 0.020	−0.96 (−1.50, −0.42), 0.001
Constant	2.78 (2.01, 3.56), <0.001	1.08 (0.83, 1.34), <0.001	−4.2 (−6.73, −1.68), 0.001	−1.74 (−2.58, −0.92), <0.001

^*Reference category was weight change 4.9% reduction to 4.9% gain