TABLE 3.
Mean Single Cell Electrophysiology Parameters
| WT | Gαi2 (−/−) | P Value | |
|---|---|---|---|
| Cell capacitance | 104 ± 4.4 pF, n=37 | 99 ± 4.3 pF, n=35 | 0.42 |
| Em | −64.8 ±2.3 mV, n=16 | −64.4±2.5 mV, n=11 | 0.91 |
| Δ | 100.6 ± 2.6 mV, n=16 | 101.4 ±5.5 mV, n=11 | 0.89 |
| APD50 | 9.9 ±1 ms, n=16 | 16.9 ± 2.2 ms, n=11 | 0.004 |
| ADP90 | 41.2 ± 5.6 ms, n=16 | 72 ±7.1 ms, n=11 | 0.002 |
| Ica | −3.9 ± 1 pA/pF, n=7 | −7.8 ± 1.1 pA/pF, n=8 | 0.022 |
| τ Ica | 38.2 ± 5.9 ms, n=7 | 16.3 ± 2.3 ms, n=8 | 0.003 |
| IK peak | 52.5 ± 5.2 pA/pF, n=8 | 38.2 ± 6.6 pA/pF, n=5 | 0.12 |
| IK plateau | 13.9 ± 2.3 pA/pF, n=8 | 11.7 ± 2.2 pA/pF, n=5 | 0.53 |
| IK τ1 | 142 ± 15.1 ms, n=8 | 166.6 ± 32.3 ms, n=5 | 0.45 |
| IK τ2 | 1122 ± 91.5 ms, n=8 | 1150 ± 126 ms, n=5 | 0.86 |
Electrophysiological parameters recorded in single cell studies from ventricular myocytes of control and Gαi2 (−/−) mice. The following parameters are presented: cell capacitance, resting membrane potential (Em), depolarisation during AP (Δ), 50 % and 90% repolarisation time (APD50, APD90), calcium current with calcium as a carrier (Ica), tau of deactivation of Ica (τ Ica), potassium current measured with 4.5 s pulse at the peak and plateau phases (IK peak, IK plateau), fast and slow inactivation constants of the K+ currents (IK τ1, IK τ2).