Table 4.
Differential gene expression in the major ion channels involved in the cardiac ventricular action potential in Gαi2 (−/−) and littermate controls.
| Gene | Gαi2 (−\−) (n=3) | Control (n=4) | Adjusted P value |
|---|---|---|---|
| Voltage gated K+ channel | |||
| KCNA5 | 6.0±0.2 | 5.2±0.5 | 0.20 |
| KCNB1 | 3.3±0.2 | 3.6±0.1 | 0.21 |
| KCND2 | 7.4±0.7 | 7.2±0.1 | 0.72 |
| KCND3 | 5.5±0.2 | 5.2±0.1 | 0.23 |
| KCNH2* | 7.7±0.2 | 6.7±0.2 | 0.01 |
| KCNQ1* | 7.5±0.3 | 6.7±0.1 | 0.03 |
| KCNIP2 | 8.5±0.5 | 7.9±0.2 | 0.16 |
| Inward Rectifier K+ channel | |||
| KCNAB2 | 4.4±0.01 | 4.4±0.05 | 0.85 |
| KCNJ2 | 6.9±0.5 | 6.8±0.1 | 0.80 |
| KCNJ3 | 6.9±0.3 | 6.8±0.1 | 0.82 |
| KCNJ11* | 7.1±0.2 | 6.3±0.3 | 0.03 |
| ABCC9 | 10.0±0.3 | 9.3±0.2 | 0.07 |
| Twin Pore K+ channel | |||
| KCNK1 | 3.7±0.05 | 3.9±0.4 | 0.80 |
| KCNK3* | 8.2±0.1 | 7.8±0.1 | 0.03 |
| KCNK6 | 5.8±0.1 | 5.7±0.2 | 0.52 |
| Na+ channel | |||
| SCN5A* | 8.5±0.3 | 7.5±0.1 | 0.02 |
| SCN1B | 5.9±0.1 | 5.8±0.2 | 0.89 |
| Ca2+ channel | |||
| CACNA1C* | 9.1±0.3 | 8.0±0.2 | 0.02 |
| CACNB2 | 7.9±0.2 | 7.5±0.2 | 0.13 |
| Misc | |||
| SLC8A1\NCX1 | 9.1±0.2 | 8.7±0.3 | 0.34 |
Expression data is presented as Mean±S.D. on a logarithmic (base 2) scale. The method for the calculation of the adjusted p value is given in the Supplementary Methods. Therefore an expression differential of 1.0 represents a twofold change in relative expression between groups. Significant differential expression is highlighted in grey.