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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Pediatr Surg. 2012 Jul;47(7):1369–1379. doi: 10.1016/j.jpedsurg.2012.02.001

Figure 4. Histology and aberrant morphogenesis of atretic duodenal development in Fgfr2IIIb-/- mouse embryos E10.5 to E13.5.

Figure 4

Transverse 7um sections of mouse duodenum taken through the atretic precursor (A, C, E and G) and corresponding three dimensional reconstructions (B, D, F and H). White arrows indicate the atretic precursor (AP) region in histological sections in A, C and E and the black arrow in G indicates the approximate area of where the AP had been at the previous time point. White arrows in B, D, F and H indicate location of the corresponding section in from A, C, E and G. Mesoderm is aqua blue, endoderm is red and the lumen is pink. Hepatic ducts are green and pancreatic ducts are yellow. Endoderm is absent in the duodenal atretic precursor region distal to the pancreatic buds by E11.5 (C and D). Involution of the mesoderm is evident at E12.5 (E and F) in this region and the defect goes to completion by E13.5 (G and H). (Bars indicate 100μM).