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. Author manuscript; available in PMC: 2013 Feb 22.
Published in final edited form as: J Am Chem Soc. 2012 Feb 10;134(7):3396–3410. doi: 10.1021/ja208791f

Figure 2.

Figure 2

Concentration-dependent inactivation of sACE-1 by Fe-NTA-lisinopril. (A) sACE-1 (1 nM) was preincubated with variable concentrations of Fe-NTA-lisinopril, and subsequently sACE-1 activity was measured from the initial cleavage rates of fluorogenic substrate. (B) Dependence of sACE-1 activity on Fe-NTA-lisinopril concentration. IC50 values were determined for all synthesized Mchelate-lisinopril complexes in the same manner.