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. 2012 Mar 28;40(13):6049–6059. doi: 10.1093/nar/gks256

Figure 7.

Figure 7.

Schematic representation of the suggested multiple roles of SUMOylated PCNA at stalled replication forks. We recommend a novel function for PCNA-SUMO in preventing DSB formation if replication stalls at DNA lesions (number one in filled circle) or in preventing the conversion of reversed replication forks to one-ended DSB (number two in filled circle). We also suggest that PCNA-SUMO prevents DSB-induced recombination and genome rearrangements (number three in filled circle).