Table 4.

Serum concentrations of tamoxifen and metabolites in patients with or without adverse effects

	No adverse effects (n = 36)	Experienced adverse effects (n = 11)
	Median (Q1, Q3) (ng/ml)	Median (Q1, Q3) (ng/ml)
Tamoxifen	15.11 (5.61, 58.87)	38.19 (25.23, 70.97)
4OHtam	0.76 (0.25, 2.94)	1.68 (1.3, 2.95)
NDtam	31.67 (11.01, 128.31)	72.69 (55.67, 140.64)
4OHNDtam	8.36 (2.28, 29.43)	17.73 (8.05, 37)
NDDtam	4.57 (1, 17.07)	10.14 (4.9, 19.47)
TamNox	2.04 (1, 12.5)	9.12 (6.74, 10.49)

Worsening of hot flashes, sweats and night sweats. Data obtained from all patients who filled in the Menopause-Specific Quality of Life questionnaire irrespective of dosing groups