Table 4.

Group Differences for Heritable Neuropsychological Measures

	Broad Bipolar Phenotype			Bipolar I Disorder			1st Degree Relatives
Trait1	χ 2	p-value	Effect Size	χ 2	p-value	Effect Size	χ 2	p-value	Effect Size
Letter Fluency	0.99	0.319	0.109	0.68	0.408	0.101
Semantic Fluency	4.34	0.037	0.228	5.83	0.016	0.298	0.34	0.561	0.062
Digit Symbol Coding	27.67	1.4×10−07	0.597	30.74	3.0×10−08	0.718	16.68	4.4×10−05	0.447
Trails A	5.05	0.025	0.246	3.01	0.083	0.213
CPT Hits	0.76	0.384	0.095	0.22	0.637	0.058
CPT Catch Trials	4.04	0.044	0.220	3.11	0.078	0.216
Digit Span Forward	3.63	0.057	0.208	2.10	0.147	0.178
Stroop	0.39	0.533	0.068	0.15	0.696	0.048
Digit Span Backward	2.04	0.153	0.156	1.25	0.264	0.136
Letter-Number Span	17.87	2.4×10−05	0.473	16.14	5.9×10−05	0.505	13.05	3.0×10−04	0.393
Spatial Delayed Response	2.60	0.107	0.176	4.67	0.031	0.266
Object Delayed Response	46.29	1.0×10−11	0.797	42.36	7.6×10−11	0.865	27.15	1.9×10−07	0.579
CVLT Learning	22.14	2.5×10−06	0.529	26.13	3.2×10−07	0.656	2.46	0.117	0.168
Digit Symbol Recall	0.64	0.424	0.087	0.10	0.757	0.038
Facial Memory Immediate	44.36	2.7×10−11	0.777	42.40	7.4×10−11	0.865	44.42	2.7×10−11	0.761
Facial Memory Delay	37.53	9.0×10−10	0.707	37.89	7.5×10−10	0.810	33.57	6.9×10−09	0.650
Matrix Reasoning	1.71	0.190	0.143	2.43	0.119	0.191
PCET Correct	0.75	0.385	0.095	0.94	0.333	0.118
Trails B	3.63	0.057	0.208	3.54	0.060	0.231

¹Statically significant group differences, after controlling the false discovery rate, are bolded