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. Author manuscript; available in PMC: 2012 Jul 22.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Mar 1;20(8):2564–2565. doi: 10.1016/j.bmcl.2010.02.087

Table 1.

Binding affinities of phenylalkylpiperazinepyridines 1–6 at sigma receptors.

Ki (nM)±SEM Selectivity
Cmpds σ1a σ2b σ1/σ2
1 41.8 ± 5.9 69.7 ± 6.3 0.60
2 34.2 ± 2.8 84.0 ± 5.9 0.41
3 97.2 ± 6.9 440 ± 20 0.22
4 21.2 ± 2.3 110.0 ± 8.6 0.19
5* 326 ± 41.2 119 ± 3.8 2.7
6* 82.9 ± 0.21 4.91 ± 0.77 16.9
*

Citations reference previously known compounds and results ref. 30

a

Displacement of [3H](+)-pentazocine

b

Displacement of [3H]DTG in presence of (+)-pentazocine