Table 2.
Opioid | Dose (mg/kg) | mdr1a/b (+/+) (AUEC) (%MPE × min) | mdr1a/b (−/−) (AUEC) (%MPE × min) | AUEC ratio mdr1a/b (−/−)/mdr1a/b (+/+) |
---|---|---|---|---|
6-Desoxymorphine | 0.2 | 367.30 ± 204.35 | 419.33 ± 322.59 | 1.14 ± 1.08 |
2 | 6266.13 ± 700.5 | 7309.87 ± 680.77 | 1.17 ± 0.17 | |
Meperidine | 50 | 6752.14 ± 917.94 | 7678.40 ± 851.59 | 1.14 ± 0.2 |
N-Phenylbutyl normeperidine | 3 | 473.91 ± 180 | 789.82 ± 177.41 | 1.67 ± 0.74 |
60 | 7102.93 ± 2241.96 | 9407.39 ± 2195.22 | 1.32 ± 0.55 |
AUEC values were calculated from 0 to 150 min and expressed as mean ± S.E.M (n = 5–6). AUEC ratio for a single s.c dose of 3 mg/kg methadone (positive control) was 2.73 ± 0.55-fold (p < 0.05) (Hassan et al., 2009).