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. Author manuscript; available in PMC: 2012 Jul 22.
Published in final edited form as: Int J Pharm. 2009 Apr 5;375(1-2):48–54. doi: 10.1016/j.ijpharm.2009.03.037

Table 2.

Area under the effect curve (AUEC) (%MPE × min) of opioids after single s.c. administration in mdr1 a/b (+/+) and mdr1 a/b (−/−) mice.

Opioid Dose (mg/kg) mdr1a/b (+/+) (AUEC) (%MPE × min) mdr1a/b (−/−) (AUEC) (%MPE × min) AUEC ratio mdr1a/b (−/−)/mdr1a/b (+/+)
6-Desoxymorphine 0.2 367.30 ± 204.35 419.33 ± 322.59 1.14 ± 1.08
2 6266.13 ± 700.5 7309.87 ± 680.77 1.17 ± 0.17
Meperidine 50 6752.14 ± 917.94 7678.40 ± 851.59 1.14 ± 0.2
N-Phenylbutyl normeperidine 3 473.91 ± 180 789.82 ± 177.41 1.67 ± 0.74
60 7102.93 ± 2241.96 9407.39 ± 2195.22 1.32 ± 0.55

AUEC values were calculated from 0 to 150 min and expressed as mean ± S.E.M (n = 5–6). AUEC ratio for a single s.c dose of 3 mg/kg methadone (positive control) was 2.73 ± 0.55-fold (p < 0.05) (Hassan et al., 2009).