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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neuroimage. 2012 Feb 1;62(4):2281–2295. doi: 10.1016/j.neuroimage.2012.01.117

Figure 4.

Figure 4

Nicotine’s impact on default-mode functioning. (A) Nicotine enhanced deactivation in DMN regions (PCC, dmPFC) in minimally deprived (~3 hrs) smokers under nicotine (relative to placebo) administration during a spatial attention task. (B) Nicotine-induced deactivation in the PCC correlates with reduced reaction time (difference values reflect Nicotine - Placebo). (Reproduced from Hahn et al., 2007). (C) Nicotine (relative to pre-nicotine baseline) reduced activity in DMN regions (vmPFC, PCC, precuneus) of non-smokers (Reproduced from Tanabe et al., 2011). (D) Example time-courses of DMN (blue) and ECN (red) activity during the resting state under nicotine and placebo conditions in two abstinent (~12 hrs) smokers. Top graphs illustrate enhanced negative coupling between the DMN and ECN following nicotine in an individual reporting decreased withdrawal symptoms following nicotine replacement. Bottom graphs show little change in DMN-ECN coupling following nicotine administration in an individual reporting no change in withdrawal symptoms (Reproduced from Cole et al 2010).