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Increased activity in DMN regions in response to cues. (A) BOLD activation in DMN regions (PCC, precuneus) to heroin-related versus neutral cues in opioid-dependent individuals (Reproduced from Wang et al., 2010). (B,C). Heroin-related cues increase BOLD activation in DMN regions (vmPFC, hippocampus) and the insula immediately prior to and after a methadone dose in opioid-dependent individuals (Reproduced from Langelben et al. 2008).
