Figure 5. GRFT, CV-N, and SVN compete with the 2G12 mAb for binding to HIV-1.
Pseudoviruses QH0692.42 (A), COT6.15-V295N/S448N (B) and COT9.6-V295N/K442N (C), the latter two with a reconstituted 2G12 epitope, were incubated with GRFT, CV-N and SVN prior to capture with the 2G12 mAb. 2G12 was competed against itself as the experimental control. Experiments were done at least 3 times.