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Cancer cells are specifically sensitive to TRAIL-induced apoptosis. Possible mechanisms to explain the selective apoptosis of cancer cell to TRAIL include (1) increase in decoy receptors (which lack the intracellular death domain) in normal cells which may activate anti-apoptotic kinase signalling pathways, (2) O-glycosylation of receptors and (3) their location in lipid rafts enhancing death inducing signalling complex (DISC) formation.
