Table 4.

Effects of various drugs on proliferation of mast cell lines

	IC50 (μM)
	NI-1	C2	HMC-1.1	HMC-1.2
Bosutinib	>2	>2	>2	0.5–1
Dasatinib	<0.003	0.003–0.006	0.0015–0.003	1–2
Erlotinib	>2	>2	>2	>2
Everolimus	<0.1	>2	>2	>2
Gefitinib	>2	>2	>2	>2
Imatinib	0.125–0.25	0.025–0.05	0.01–0.025	>2
Lapatinib	>2	>2	>2	>2
Masitinib	0.1–0.2	0.025–0.05	0.005–0.01	>2
Midostaurin	<0.1	<0.1	0.1–0.25	0.1–0.25
Nilotinib	0.2–0.3	0.1–0.2	0.025–0.05	1–2
NVP-BEZ235	0.01–0.05	0.01–0.05	0.05–0.075	0.01–0.05
Sunitinib	0.006–0.013	0.006–0.013	0.003–0.006	>2
Sorafenib	0.1–0.25	0.005–0.1	0.01–0.015	>2
Tozasertib	<0.1	>2	>2	<0.1
Vorinostat	0.1–0.5	0.1–0.5	0.5–1	0.5–1

Cells were incubated with various concentrations of targeted drugs at 37°C for 48 h. Then, ³H-thymidine uptake was measured. The mean IC₅₀ values from at least three independent experiments are shown.