Table 2.
Representative shared and unique target genes regulated by HIF1α and HIF2α
| Gene | Function | HIF1α | HIF2α | Cell type |
|---|---|---|---|---|
| GLUT1 | Glucose transport | + | + | RCC27, mouse ES36, 37 |
| ADRP | Lipid metabolism | + | + | RCC27 |
| CAXII | pH homeostasis | + | + | RCC27 |
| FILAG | Cytoskeletal structure | + | + | RCC27 |
| IL-6 | Immune cytokine | + | + | RCC27 |
| ADM1 | Angiogenesis | + | + | RCC27 |
| VEGF | Angiogenesis | + | + | RCC, Hep3B27-29 |
| VEGF | Angiogenesis | + | − | Mouse EC51, mouseES36,37 |
| BNIP3 | Autophagy, apoptosis | + | − | RCC28 |
| HK1 | Glycolysis | + | − | mouse ES36, 37 |
| HK2 | Glycolysis | + | − | RCC27, mouse ES36, 37 |
| PFK | Glycolysis | + | − | RCC27, mouse ES36,37 |
| ALDA | Glycolysis | + | − | RCC27, mouse ES36, 37 |
| PGK1 | Glycolysis | + | − | RCC27, mouse ES36, 37 |
| LDHA | Glycolysis | + | − | RCC27, mouse ES36, 37 |
| INOS | NO production | + | − | Macrophages49 |
| ARG | Inhibitor of NO production | − | + | Macrophages49 |
| EPO | Erythropoiesis | − | + | Kidney41, 42, 65, liver188 |
| OCT4 | Stem cell identity | − | + | Mouse ES157 |
| SCGB3A1 | Secretoglobin 3A1 | − | + | NSCLC26 |
| TGFα | Growth Factor | − | + | RCC28, 189 |
| CCND1 | Cell cycle progression | − | + | RCC28 |
| DLL4 | NOTCH signaling, EC branching | − | + | Mouse ECS53 |
| ANG2 | Blood vessel remodeling | − | + | Mouse ECS53 |