TABLE 1.

General Health and One-Carbon Metabolite Measurements

	WTC	WTFD	GC	GFD
Weight
Males	26.95 ± 0.60	27.42 ± 0.83	27.07 ± 0.72	27.48 ± 0.44
Females	21.81 ± 0.68	21.54 ± 0.50	21.74 ± 0.51	21.10 ± 0.35
Plasma Folate (ng/ml)
Males	90.5 ± 10.4	36.8 ± 7.2*	146.0 ± 22.7†	26.6 ± 6.1*
Females	74.5 ± 11.0	37.3 ± 12.1	111.9 ± 9.8†	28.0 ± 3.4*
Liver Folate (μg/g)
Males	72.4 ± 2.3	33.4 ± 1.3*	70.4 ± 4.5	37.1 ± 0.8*‡
Homocysteine (μM)
Females	5.0 ± 1.2	10.2 ± 1.5¥	8.1 ± 1.4	9.6 ± 1.9¥

All values represent the average ± SEM.

^*values significant less than WTC

^†values significantly larger than WTC

^‡values significant larger than WTFD.

^¥folate deficient groups combined significantly larger than control groups combined.

Weight: n's = 9 – 15 / group. Plasma and Liver Folate: n's = 4 – 9 / group. Homocysteine: n's = 5 – 6 / group.

Abbreviations: WTC, wildtype control; WTFD, wildtype folate deficient; GC, GCPII^+/- control; GFD, GCPII^+/- folate deficient.