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. 2011 Jan;3(1):50–66. doi: 10.1002/emmm.201000112

Figure 2. Mouse lines carrying reciprocal Df and Dp on chromosome 11.

Figure 2

  1. Schematic representation of the segmental aneuploidy region on chromosome 11 containing 26 annotated and one unknown gene (mouse NCBI m37 assembly, April 2007, C57BL/6J reference strain) and syntenic region on human chromosome 17 (Human GRCh37 assembly February 2009). Df11(1)/+, WT and Dp11(1)/+ mice carried one, two and three copies, respectively, of genes in the interval.
  2. CGH analysis of Df11(1)/+ versus WT and Dp11(1)/+ versus WT littermates confirmed expected gene dose changes across the rearrangement. Negative and positive log ratios indicate, respectively, loss and gain of genetic material.