Skip to main content
. 2011 Jan;3(1):50–66. doi: 10.1002/emmm.201000112

Figure 6. Contact hypersensitivity and T cell function.

Figure 6

  1. A significant positive gene dose-dependent effect was observed for ear swelling following local application of DNFB. Ear thickness was measured at 24, 48 and 72 h following DNFB treatment in mice that had been sensitized by DNFB pre-treatment (mean ± SEM; Df11(1)/+, N = 22; WT, N = 42; Dp11(1)/+, N = 20; *p < 0.05, ***p < 0.001).
  2. A significant positive gene dose-dependent effect was observed for the fraction of cultured naïve splenic T cells (Th0 cells) immunostaining for intracellular IL-17 (N = 4).
  3. Quantitative real-time PCR revealed a positive gene dose-dependent effect on IL-17 mRNA expression in Th0 cells cultured for 5 days and stimulated acutely with cytokines. Data represents fold change compared to WT animals. N = 2 for each genotype.
  4. The gene dose-dependent effect on fraction of IL-17+ T cells was occluded in cytokine-induced polarized T cells (Th17 cells, mean ± SEM, N = 4).