A. Normal body weight in Df11(1)/+ and Dp11(1)/+ mice 4, 7, 10 and 13 weeks after initiation of high-fat diet (mean ± SEM; Df11(1)/+, N = 14; WT, N = 18; Dp11(1)/+ N = 11).
B. Significant negative gene dose-dependent effect on fasted blood glucose concentration in mice on normal (week 15), but not after 15 weeks of high-fat diet treatment (week 30).
C. Significant negative gene dose-dependent effect on glucose clearance following intra-peritoneal dextrose challenge after high-fat diet treatment for 15 weeks (AUC = area under the curve; Df11(1)/+, N = 20; WT, N = 36; Dp11(1)/+, N = 15 Controls were age-matched mice on a normal diet: Df11(1)/+, N = 7; WT, N = 19; Dp11(1)/+, N = 11 *p < 0.05).
D. Significant negative gene dose-dependent effect on plasma cholesterol in mice treated for 15 weeks with high-fat (week 30), but not normal diet (week 14 mean ± SEM; Df11(1)/+, N = 23; WT, N = 49; Dp11(1)/+, N = 22).
E,F. Significant positive gene dose-dependent effect on normalized (E) gonadal fat, but not (F) liver weight (mean ± SEM; Df11(1)/+, N = 20; WT, N = 35; Dp11(1)/+, N = 15). Weight of Gonadal fat and liver for each animal were normalized to total body weight.
