Figure 9. Contact hypersensitivity in heterozygous Stat5ab and Stat3 knockout mice.

• A. A significant reduction of ear swelling was observed in heterozygous Stat5ab^KO, but not Stat3^KO mice following local application of DNFB. Ear thickness was measured at 24, 48 and 72 h following DNFB treatment in mice that had been sensitized by DNFB pre-treated on the abdomen 5 days earlier (mean ± SEM; WT, N = 15; Stat5ab^KO/+, N = 13; Stat3^KO/+, N = 10; Stat5ab^KO/Stat3^KO, N = 6; *p < 0.05, **p < 0.01, ***p < 0.001).
• B–D. Significant reduction in peripheral blood (C) CD8+, but not (D) CD4+ T cells or (B) total white blood cells (mean ± SEM; WT, N = 9; Stat5ab^KO/+, N = 9; Stat3^KO/+, N = 7; Stat5ab^KO/Stat3^KO, N = 6; *p < 0.05, **p < 0.01, ***p < 0.001).