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. 2012 Jul 23;6:52. doi: 10.3389/fncom.2012.00052

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Copyright © 2012 Culmone and Migliore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Overall improvement of a K_A-treatment. All contour plots show, for each condition of synaptic weight and % of impaired surface, the ratio between the average value of spike probability and its value under control conditions (i.e., healthy neuron); healthy condition is represented by a ratio around 1. (A) average ratio for 11 trials (differing each other for redistribution of damaged neuronal area, synapses location and activation time) under healthy conditions; (B) the ratio is decreased by AD, with a stronger effect for higher portion of damaged membrane; (C) after K_A-treatment, the ratio is restored to a value around 1 (healthy conditions) for a wide range of parameters.