(A,B) Expression of TGF-1β; (A,C) Collagen-I; (A,D) collagen-III; (A,E) TNFα; and (A,F,G) adhesion molecules ICAM and VECAM in lung tissues from control group, TAC-induced M-HF or HF groups. (H) The diagram shows the potential mechanism of TAC-induced pulmonary remodeling, pulmonary hypertension and mortality. *p<0.05 vs control group; #p<0.05 vs. corresponding M-HF group.