Table 1.
Receptor | Percent inhibition | Radioligand | Kd (M) |
---|---|---|---|
Adrenergic, a1A | 55.78 | [3H]-7-meoxy-prazosin | 4.0E–10 |
Adrenergic, a2A (h) | 61.20 | [3H]-MK-912 | 0.5E–9 |
DA, D1 (hr) | 97.34 | [3H]-SCH23390 | 2.0E–9 |
DA, D2 (hr) | 87.37 | [3H]-spiperone | 1E–10 |
DA, D3 | 82.92 | [3H]7-OH-DPAT | 0.9E–9 |
Serotonin, 5HT1A (hr) | 100.79 | [3H]8-OH-DPAT | 0.8E–9 |
Serotonin, 5HT1D | 75.89 | [3H]-5-CT | 2.5E–9 |
Serotonin, 5HT4 | 73.60 | [3H]GR 113808 | 0.1E–9 |
Serotonin, 5HT7 (hr) | 76.81 | [3H]-LSD | 3E–9 |
Cannabinoid, CB1 (hr) | −5.64 | [3H]-CP 55940 | 0.6E–9 |
Muscarinic, M1 (hr) | 4.65 | [3H]scopolamine,N-methyl | 5E–11 |
Opiod, Mu (hr) | 6.96 | [3H]-diprenorphine | 2E–10 |
Receptors in bold letters indicate significantly high-binding affinity of l-THP. Percent inhibition of 50% or greater is taken as active binding. Kd values of radioligands are listed as reference in the far right column. H, human; hr, human recombinant. DPAT, Dipropylamino-tetrahydronaphthalen; CT, Carboxamidotryptamine; LSD, Lysergic acid diethylamide.