Table 2.

Acute l-THP administration-induced regional average of AUC% at each dose level

ROIs	l-THP injection dosages (mg/kg)
	0 (n=4)	5 (n=4)	10 (n=4)	20 (n=4)	40 (n=4)
NAc	0.01±0.04	−0.01±0.05	−0.16±0.02	−0.31±0.07	−0.35±0.09
SNR	0.17±0.04	−0.18±0.13	−0.26±0.16	−0.52±0.23	−1.01±0.22
Ins	−0.06±0.08	−0.29±0.05	−0.54±0.11	−0.62±0.24	−0.82±0.26
HIPP	0.02±0.02	−0.25±0.06	−0.42±0.22	−0.82±0.09	−1.20±0.24
IL	0.10±0.03	−0.03±0.03	−0.15±0.08	−0.35±0.07	−1.33±0.31
Motor cortex	−0.02±0.02	−0.20±0.05	−0.32±0.13	−0.52±0.04	−1.20±0.18
Somatosensory cortex	0.06±0.05	−0.15±0.07	−0.26±0.05	−0.48±0.55	−1.08±0.12
Auditory cortex	−0.00±0.13	−0.12±0.06	−0.31±15	−0.29±0.04	−1.28±0.23
Retrosplenium	−0.35±0.02	−0.31±0.12	−0.53±0.30	−1.28±0.42	−1.37±0.20
VTA	0.37±0.12	−0.34±0.08	−0.63±0.12	−0.69±0.18	−1.58±0.29
Hypoth	0.05±0.03	−0.29±0.11	−0.22±0.08	−0.63±0.09	−0.68±0.18
Thal	−0.04±0.02	−0.04±0.04	−0.38±0.05	−0.58±0.06	−0.94±0.15
Caudate putamen	−0.05±0.08	−0.32±0.15	−0.57±0.25	−0.91±0.07	−1.12±0.17
BNST	−0.08±0.05	−0.22±0.30	−0.48±0.28	−0.61±0.14	−0.75±0.32
Cl	0.01±0.03	−0.02±0.04	0.03±0.02	−0.04±0.03	−0.03±0.04

The first 14 regions (in BOLD letters), obtained from Fig. 3F, which demonstrated their dose-response activities (mean AUC%) to l-THP administration, as well as a nonresponsive region (Cl), are listed.