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Permeability values of Vandetanib across MDCK cell monolayers
| Permeability (×106)cm/sec |
||||
|---|---|---|---|---|
| Cell line | Drug ± Inhibitor | A-B | B-A | Efflux Ratio |
| MDCK-WT | Vandetanib | 7.57±0.52 | 8.08±0.17 | 1.06 |
| MDCK-MDR1 | Vandetanib | 5.73±0.29 | 4.66±0.26 | 0.81 |
| MDCK-Bcrp1 | Vandetanib | 5.66±1.26 | 42.32±2.64 | 7.5 |
| Vandetanib+Ko143 | 8.58±0.63 | 8.58±0.69 | 1 | |
| Vandetanib+Everolimus | 7.29±1.24 | 10.03±0.79 | 1.4 | |
| Vandetanib+Temsirolimus | 10.80±1.22 | 11.81±0.30 | 1.1 | |
