. Author manuscript; available in PMC: 2013 Sep 15.

Published in final edited form as: Int J Pharm. 2012 May 23;434(1-2):306–314. doi: 10.1016/j.ijpharm.2012.05.028

Table. II.

Plasma and brain pharmacokinetic parameters obtained by noncompartmental analysis of the concentration-time profile data after an i.v bolus dose of vandetanib in the absence and presence of elacridar (GF120918) in FVB wild type mice

PK parameters	vandetanib alone		vandetanib+GF120918

	Plasma	Brain	Plasma	Brain
λ_z (h-1)	0.43	0.42	0.44	0.16
half-life (h)	1.60	1.65	1.58	4.28
Clearance(ml/min/kg)	9.36		10.33
Volume of distribution (l/kg)	1.30		1.41
AUC_(0→tlast)(μ*gmin/ml)**	305.3 ± 12.2	62.9 ± 0.8	276.3 ±11.5	177.3 ± 18.9
AUC_{(0→tlast)brain}/AUC_{(0→tlast)plasma}	0.206		0.642