Figure 7.

Schematic illustration of the signaling transduction pathway in tPA-induced NF-κB activation. tPA promotes the interaction and aggregation of annexin A2 and CD11b, inducing the clustering and outside-in signaling of CD11b integrin, which leads to the activation of the downstream ILK, phosphorylation of IκB, and subsequent activation of NF-κB pathway. (A–C) Blockade of any step within this signaling cascade by various strategies eliminates tPA-induced NF-κB activation. (D) Ectopic expression of wild-type ILK mimics tPA effect.