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. 2012 Jul 17;61(8):2146–2154. doi: 10.2337/db11-0578

FIG. 2.

FIG. 2.

Methazolamide improved glucose tolerance in DIO mice. A: Glucose tolerance test (2 g/kg glucose i.p.) in DIO mice treated with vehicle (35% PEG400) (black bars) or 50 mg/kg/day MTZ, DCP, CTD, or FUR (white bars) for 14 days. Data show the mean incremental area under the glucose curve (iAUC) ± SE. *P < 0.05 vs. corresponding vehicle treatment group, n = 4–10. Circulating blood glucose (B) and insulin levels (C) during an intraperitoneal glucose tolerance test in animals dosed with vehicle (black circles), 20 (white triangles), 50 (white diamonds), or 100 (white circles) mg/kg/day MTZ for 14 days are shown. Data represent the mean ± SE of 5 to 6 mice per treatment group. *P < 0.05 vs. corresponding vehicle; #P < 0.05, 50 mg/kg MTZ vs. corresponding vehicle.