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. 2012 Jul 17;61(8):1994–2003. doi: 10.2337/db11-1688

FIG. 3.

FIG. 3.

Systemic administration of IL-10 improves SPX-induced proinflammatory responses of the liver and liver dysfunction. A: Representative H-E staining and immunostaining for F4/80 in liver sections derived from each group. Scale bar = 100 μm. B: TG contents of the liver in each group (n = 6). C: Serum ALT levels in each group (n = 6). D: Expression of F4/80 in the liver of each group (n = 6). E–H: TNF-α (E), IL-1β (F), MCP-1 (G), and IL-10 (H) contents of the liver in each group (n = 6). J: The ratio of IL-10 to TNF-α in the liver of each group (n = 6). *P < 0.05 vs. Standard Sham group, #P < 0.05 vs. HF Sham group. Treatment groups: Standard Sham, fed Standard, administered m-albumin, and given sham operation; HF Sham, fed HF, administered m-albumin, and given sham operation; HF SPX, fed HF, administered m-albumin, and given splenectomy; HF SPX+IL-10, fed HF, administered IL-10, and given splenectomy; Pair-fed, administered m-albumin, given sham operation, and fed the same amount of food as consumed by the HF SPX group. (A high-quality digital representation of this figure is available in the online issue.)