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. 2012 Jul 17;61(8):1994–2003. doi: 10.2337/db11-1688

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© 2012 by the American Diabetes Association.

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FIG. 7. — SPX does not affect fat accumulation or inflammatory responses in the liver of IL-10KO mice. A: Representative H-E staining and immunostaining for F4/80 in liver sections derived from each group. Scale bar = 100 μm. B: Comparison of hepatic TG contents in each group (n = 6). C: F4/80 expression in the liver of each group (n = 6). D−F: Protein levels of TNF-α (D), IL-1β (E), and MCP-1 (F) in the livers of each group (n = 6). G: Comparison of serum ALT levels in each group (n = 6). *P < 0.05 vs. Sham (Wild) group. Treatment groups: Sham, fed HF, administered m-albumin, and given sham operation; SPX, fed HF, administered m-albumin, and given splenectomy; SPX+IL-10, fed HF, administered r-IL-10, and given splenectomy. Wild, wild-type mice. (A high-quality digital representation of this figure is available in the online issue.)