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. 2012 Jul 17;61(8):2045–2053. doi: 10.2337/db11-1143

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© 2012 by the American Diabetes Association.

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FIG. 4. — MMP-9 in CD11b-positive cell migration. Compared with control (A and B), CD11b-positive cells (green) in association with insulin-positive islet (red) transplant are indicated in wild-type mouse liver (C and D) as well as in MMP-9 knockout (KO) liver (E and F) with transplanted islets (red). More CD11b-positive cells migrated into wild-type mouse liver (C and D) with transplanted islets compared with MMP-9 knockout liver (E and F) with transplanted islets. B, D, and F: Costaining of nucleus with DAPI (blue) is added. Magnification ×200 (n = 3). Fluorescence-activated cell sorter data are placed next to respective immunostaining figures. There were a total of 67% of CD11b-positive cells in wild-type transplanted mice compared with 45% in MMP-9 knockout transplanted mice. All figures are representative of three independent experiments. (A high-quality digital representation of this figure is available in the online issue.)