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. 2012 Jul 17;61(8):2045–2053. doi: 10.2337/db11-1143

FIG. 6.

FIG. 6.

MMP-9 inhibition and reduction of macrophages and neutrophils. A: Leukocyte migration was quantitated in islet-transplanted liver sections with and without in vivo MMP-9 inhibition. CD11b (Mac-1) staining revealed significant inhibition of CD11b-positive cell migration toward islet-transplanted liver in captopril or MMP-2/-9 inhibitor–treated and MMP-9 knockout (KO) mice compared with wild-type islet-transplanted mice (WT-Tx) (**P < 0.001, n = 3 mice). B: Number of Ly6G-positive cells also was reduced in captopril, MMP-2/-9 inhibitor–treated, and MMP-9 knockout animals compared with wild-type islet-transplanted mice. (**P < 0.001, n = 3, three fields per section).