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MMP-9 inhibitor peptide and graft function. MMP-2/-9 inhibitor (15 mg/kg) was injected intravenously for 7 days to mice transplanted with pig islets (n = 4 in each group). A: Mean blood glucose levels in the group treated with the inhibitor (▲) were lower compared with the control group (■). B: Statistical analysis showed a significant difference in mean blood glucose value (*P < 0.05). The day of graft loss was defined as the last one of successive levels of >16.7 mmol/L glucose.
