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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nat Biotechnol. 2012 Feb 26;30(3):265–270. doi: 10.1038/nbt.2136

Figure 4. Distribution of effect sizes for all possible substitution mutations in three mammalian enhancers.

Figure 4

For the three enhancers studied (two replicate libraries for LTV1), plotted is the cumulative fraction of substitutions possessing a given effect size expressed as the absolute value of the effect size of a given substitution. For example, across the three enhancers, between ~80% and ~95% of substitutions influence transcriptional activity by less than a factor of 1.5.