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. Author manuscript; available in PMC: 2012 Jul 23.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Aug 14;375(3):425–429. doi: 10.1016/j.bbrc.2008.08.022

Figure 3. Effect of Combined S1P and Sphingosine Postconditioning on Recovery from 75 Min of Ischemia.

Figure 3

Ex vivo hearts were equilibrated for 20 minutes and then exposed to 75 min of global ischemia. This was followed by 40 min of reperfusion in the presence of either vehicle (Ctl), 0.4 μM S1P, 0.4 μM sphingosine, or 0.2 μM S1P plus 0.2 μM sphingosine. Recovery of LVDP (A) is expressed as a percentage of the pre-index ischemia value. The infarct size (B) is expressed as a percentage of the area at risk determined at the end of the 40 min reperfusion. The data represent the mean and the error bars reflect the standard deviation (n≥4). Statistical significance (p<0.05) is indicated by (*)