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. 2012 Jul 23;7(7):e41542. doi: 10.1371/journal.pone.0041542

Figure 2. PTHrP NLS and C terminus deficiency results in a reduction of neural stem cells.

Figure 2

Representative micrographs of sections in (A) the subventricular zone (SVZ) and (B) the hippocampus (HP) from the brains of E18.5 WT and Pthrp−/− (KO) mice and E18.5, P1, P7 and P14 WT and Pthrp KI mice immunostained for PCNA (brown color, magnification, ×400). PCNA positive cell numbers in (C) SVZ and (D) HP (number/per field). Each value is the mean±SEM of determinations in 5 mice of each group. *, P<0.05; **, P<0.01; ***, P<0.001 in Pthrp KI mice relative to wild-type littermates. ##, P<0.01; ###, P<0.001 at the time point relative to the prior observed time point in WT mice. ▴, P<0.05; ▴▴, P<0.01; ▴▴▴, P<0.001 at the time point relative to the prior observed time point in Pthrp KI mice.