Table 3. Main results of the pooled data in the present meta-analysis.
No. (cases/controls) | GG vs TT | (GG+GT) vs TT | GG vs (GT+TT) | |||||||
OR (95%CI) | P | P (Q-test) | OR (95%CI) | P | P (Q-test) | OR (95%CI) | P | P (Q-test) | ||
Total | 7196/8456 | 1.14 (0.95–1.37) | 0.164 | 0.001 | 1.05 (0.92–1.19) | 0.502 | 0.001 | 1.12 (0.99–1.27) | 0.084 | 0.035 |
Ethnicity | ||||||||||
Asian | 2905/3569 | 1.23 (0.91–1.66) | 0.181 | 0.004 | 1.18 (0.96–1.46) | 0.108 | 0.036 | 1.14 (0.93–1.40) | 0.206 | 0.024 |
Caucasian | 4158/4632 | 1.05 (0.86–1.27) | 0.654 | 0.106 | 0.96 (0.86–1.07) | 0.434 | 0.218 | 1.08 (0.92–1.27) | 0.368 | 0.183 |
African | 133/255 | 0.73 (0.14–3.83) | 0.711 | – | 0.77 (0.45–1.34) | 0.360 | – | 0.76 (0.15–3.99) | 0.749 | – |
Smoking status | ||||||||||
Ever smoking | 3309/3056 | 1.25 (0.78–1.99) | 0.354 | 0.000 | 1.08 (0.77–1.51) | 0.652 | 0.000 | 1.21 (0.90–1.62) | 0.205 | 0.004 |
Never smoking | 815/1481 | 1.76 (1.36–2.29) | 0.000 | 0.926 | 1.48 (1.22–1.81) | 0.000 | 0.501 | 1.37 (1.11–1.69) | 0.004 | 0.994 |
Histological types | ||||||||||
AC | 2355/5802 | 1.24 (0.90–1.70) | 0.188 | 0.003 | 1.07 (0.88–1.31) | 0.503 | 0.016 | 1.21 (0.96–1.52) | 0.102 | 0.023 |
SQCC | 1770/4833 | 1.12 (0.83–1.52) | 0.456 | 0.012 | 1.03 (0.80–1.34) | 0.814 | 0.003 | 1.13 (0.96–1.33) | 0.150 | 0.242 |
Source of control | ||||||||||
HB | 5116/5330 | 1.06 (0.88–1.27) | 0.549 | 0.053 | 1.00 (0.87–1.16) | 0.993 | 0.026 | 1.06 (0.94–1.18) | 0.336 | 0.310 |
PB | 2080/3126 | 1.36 (0.92–2.01) | 0.121 | 0.013 | 1.15 (0.88–1.49) | 0.301 | 0.014 | 1.28 (0.96–1.71) | 0.090 | 0.055 |
Gender | ||||||||||
Male | 2253/2760 | 0.99 (0.75–1.31) | 0.951 | 0.064 | 0.94 (0.79–1.13) | 0.533 | 0.091 | 1.02 (0.81–1.29) | 0.843 | 0.098 |
Female | 1740/2033 | 1.28 (0.95–1.73) | 0.098 | 0.165 | 1.01 (0.86–1.18) | 0.926 | 0.313 | 1.29 (1.04–1.59) | 0.019 | 0.336 |
AC: adenocarcinoma; SQCC: squamous cell carcinoma; PB: population-based; HB: hospital-based.