Figure 1. T4 enhances survival during meningococcal infection.

(A-D) Mice (n = 10–12 per group) were treated with T4 (500 ng) or vehicle (control) for three days. On the second day of treatment, mice were challenged i.p. with 10⁸ CFU of the N. meningitidis strain FAM20. (A) Survival of T4-treated and control mice after bacterial infection. Bacterial counts in blood (B), spleen (C) and liver (D) of mice at 24 h p.i. were determined. (E–F) Mice were challenged with 10⁸ CFU of bacteria and treated with T4 (250–1000 ng/mouse) at 4 h and 24 h p.i. The control group was treated with vehicle. (E) Survival and (F) bacterial counts in blood of mice at 24 h p.i. were measured. *, P<0.05 (Nonparametric Mann-Whitney test in A and E, Student’s t-test in B–D, F). Symbols represent individual mice and the horizontal lines represent mean of the values.