Table 3. Multivariate analysis for correlation of biotinidase expression with disease free survival.

				95% CI for HR
Univariate	Parameter	P value	Hazards ratio (HR)	Lower	Upper
	Age	0.595	0.8	0.3	1.9
	Gender	0.136	2.1	0.8	5.5
	Tumor stage	<0.001	2.2	1.5	3.2
	Overall stage	0.140	1.3	0.9	1.8
	Histology type	0.676	1.1	0.8	1.4
	Histology grade	0.374	23.9	0.02	26100.0
	Nodal status	0.001	12.2	2.8	53.8
	Extrathyroidal extension	<0.001	9.0	3.1	26.4
	Biotinidase Nuclear loss	0.014	5.4	1.2	24.1
	Biotinidase Cytoplasmic loss	0.022	2.8	1.1	7.2
	Biotinidase Overall loss	0.019	3.1	1.2	7.8
Multivariate
	Extrathyroidal extension	0.015	4.1	1.3	12.8
	Nodal status	0.035	5.6	1.1	27.8