Table 3. Results of the SCD meta-analysis for the two significant SNPs.
| SNP | Model | Population cohorts, HR (95% CI) | Autopsy studies, OR (95% CI) | Fixed-effects meta-analysis | ||||||
| FINRISK 1992 | FINRISK 1997 | FINRISK 2002 | Health 2000 | HSDS | TASTY | I2 | RR (95% CI) | P-value | ||
| rs41312391 | 1 | 1.43 (1.09–1.87) | 1.32 (1.04–1.68) | 1.41 (0.97–2.04) | 1.05 (0.76–1.46) | 1.20 (0.78–1.83) | 1.09 (0.72–1.62) | 0.00 | 1.27 (1.11–1.45) | 3.4×10−4 |
| rs41312391 | 2 | 1.53 (1.16–2.01) | 1.33 (1.03–1.73) | 1.44 (0.99–2.08) | 1.07 (0.76–1.50) | NA | NA | 0.00 | 1.35 (1.16–1.57) | 1.2×10−4 |
| rs2200733 | 1 | 1.15 (0.83–1.59) | 1.15 (0.88–1.49) | 1.55 (1.04–2.32) | 1.42 (1.02–1.98) | 1.12 (0.71–1.78) | 1.58 (1.00–2.50) | 0.00 | 1.28 (1.11–1.48) | 7.9×10−4 |
| rs2200733 | 2 | 1.06 (0.77–1.47) | 1.23 (0.93–1.63) | 1.67 (1.11–2.50) | 1.30 (0.92–1.82) | NA | NA | 0.00 | 1.26 (1.07–1.49) | 0.006 |
Model 1: Age was used as the time scale and sex and geographic region were adjusted for. Model 2: Sex, geographic region, HDL-total cholesterol ratio, systolic blood pressure, prevalent diabetes, BMI, current and former smoking status, physical activity, and prevalent CHD were adjusted for. BMI = body mass index, CHD = coronary heart disease, CI = confidence interval, HDL = high-density lipoprotein cholesterol, HR = hazard ratio (in Cox regression), HSDS = The Helsinki Sudden Death Study, I2 = measure of heterogeneity between studies, OR = odds ratio (in logistic regression), RR = relative risk, SCD = sudden cardiac death, SNP = single nucleotide polymorphism, TASTY = The Tampere Autopsy Study.