Table 5. Association between CTSS SNPs and body fat distribution change during the study.
| SNP | Phenotype | Effect | Estimate | P | SE | CI 95% lower | CI 95% higher |
| rs7511673 (SNP N°1) | Waist (RSC) | main effect | −0.04 | 0.01 | 0.02 | −0.08 | −0.01 |
| interaction diet ED | 0.02 | 0.75 | 0.06 | −0.10 | 0.14 | ||
| interaction diet GI | 0.00 | 0.75 | 0.01 | −0.02 | 0.01 | ||
| interaction diet protein | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.00 | 0.79 | 0.01 | −0.02 | 0.01 | ||
| Waist for given BMI | main effect | −0.03 | 0.03 | 0.01 | −0.05 | 0.00 | |
| (RSC) | interaction diet ED | 0.04 | 0.44 | 0.05 | −0.05 | 0.12 | |
| interaction diet GI | 0.00 | 0.72 | 0.01 | −0.02 | 0.01 | ||
| interaction diet protein | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.00 | 0.61 | 0.01 | −0.01 | 0.01 | ||
| rs11576175 (SNP N°2) | Waist (RSC) | main effect | 0.01 | 0.82 | 0.03 | −0.05 | 0.06 |
| interaction diet ED | −0.01 | 0.91 | 0.10 | −0.21 | 0.19 | ||
| interaction diet GI | 0.00 | 0.68 | 0.01 | −0.03 | 0.02 | ||
| interaction diet protein | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.02 | 0.16 | 0.01 | −0.01 | 0.04 | ||
| Waist for given BMI | main effect | 0.00 | 0.98 | 0.02 | −0.04 | 0.04 | |
| (RSC) | interaction diet ED | −0.05 | 0.50 | 0.07 | −0.20 | 0.10 | |
| interaction diet GI | −0.01 | 0.24 | 0.01 | −0.02 | 0.01 | ||
| interaction diet protein | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.02 | 0.14 | 0.01 | −0.01 | 0.04 | ||
| rs10888390 (SNP N°3) | Waist (RSC) | main effect | −0.03 | 0.04 | 0.02 | −0.07 | 0.00 |
| interaction diet ED | 0.02 | 0.72 | 0.06 | −0.10 | 0.15 | ||
| interaction diet GI | 0.00 | 0.95 | 0.01 | −0.01 | 0.02 | ||
| interaction diet protein | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.00 | 0.85 | 0.01 | −0.01 | 0.02 | ||
| Waist for given BMI | main effect | −0.02 | 0.06 | 0.01 | −0.05 | 0.00 | |
| (RSC) | interaction diet ED | 0.03 | 0.48 | 0.05 | −0.06 | 0.12 | |
| interaction diet GI | 0.00 | 0.71 | 0.01 | −0.02 | 0.01 | ||
| interaction diet protein | 0.00 | 0.22 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.00 | 0.90 | 0.01 | −0.01 | 0.01 | ||
| rs1136774 (SNP N°4) | Waist (RSC) | main effect | −0.02 | 0.18 | 0.02 | −0.05 | 0.01 |
| interaction diet ED | −0.01 | 0.92 | 0.06 | −0.13 | 0.11 | ||
| interaction diet GI | 0.00 | 0.73 | 0.01 | −0.01 | 0.01 | ||
| interaction diet protein | 0.00 | 0.96 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.01 | 0.43 | 0.01 | −0.01 | 0.02 | ||
| Waist for given BMI | main effect | −0.02 | 0.24 | 0.01 | −0.04 | 0.01 | |
| (RSC) | interaction diet ED | 0.00 | 0.96 | 0.05 | −0.10 | 0.09 | |
| interaction diet GI | 0.00 | 0.53 | 0.01 | −0.02 | 0.01 | ||
| interaction diet protein | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | ||
| interaction diet protein % | 0.00 | 0.70 | 0.01 | −0.01 | 0.01 |
Overall Meta analysis estimates (β or odd ratios), p values, standard error and 95% confidence intervals for associations between SNPs and body fat distribution change during the study, ED: energy density, GI: glycemic index. RSC: random subcohort.