Table 1. Summary of single nucleotide polymorphisms analyzed for pro- and anti-inflammatory cytokine genes and the growth mixture model analysis for general sleep disturbance scale total score.
| Gene | SNP | Position | Chr | MAF | Alleles | Chi Square | p-value | Model |
| IFNG1 | rs2069728 | 66834051 | 12 | .079 | G>A | 2.18 | .335 | A |
| IFNG1 | rs2069727 | 66834490 | 12 | .411 | A>G | 1.00 | .608 | A |
| IFNG1 | rs2069718 | 66836429 | 12 | .442 | C>T | 2.16 | .340 | A |
| IFNG1 | rs1861493 | 66837463 | 12 | .264 | A>G | 0.62 | .733 | A |
| IFNG1 | rs1861494 | 66837676 | 12 | .279 | T>C | 0.08 | .961 | A |
| IFNG1 | rs2069709 | 66839970 | 12 | .008 | G>T | FE | 1.000 | A |
| IFNG1 | HapA3 | n/a | 0.62 | .733 | ||||
| IFNG1 | HapA5 | n/a | 1.00 | .608 | ||||
| IFNGR1 | rs9376268 | 137574444 | 6 | .246 | G>A | 1.47 | .479 | A |
| IL1B | rs1071676 | 106042060 | 2 | .198 | G>C | 2.23 | .328 | A |
| IL1B | rs1143643 | 106042929 | 2 | .331 | G>A | 0.21 | .902 | A |
| IL1B | rs1143642 | 106043180 | 2 | .095 | C>T | 1.98 | .371 | A |
| IL1B | rs1143634 | 106045017 | 2 | .196 | C>T | 2.33 | .312 | A |
| IL1B | rs1143633 | 106045094 | 2 | .345 | G>A | 0.25 | .883 | A |
| IL1B | rs1143630 | 106046282 | 2 | .103 | C>A | 0.37 | .831 | A |
| IL1B | rs3917356 | 106046990 | 2 | .432 | A>G | 1.04 | .594 | A |
| IL1B | rs1143629 | 106048145 | 2 | .353 | T>C | 0.82 | .663 | A |
| IL1B | rs1143627 | 106049014 | 2 | .390 | T>C | 1.45 | .485 | A |
| IL1B | rs16944 | 106049494 | 2 | .380 | G>A | 1.94 | .379 | A |
| IL1B | rs1143623 | 106050452 | 2 | .248 | G>C | 2.15 | .341 | A |
| IL1B | rs13032029 | 106055022 | 2 | .428 | C>T | 1.12 | .570 | A |
| IL1B | HapA1 | n/a | 3.87 | .145 | ||||
| IL1B | HapA3 | n/a | FE | .191 | ||||
| IL1B | HapA4 | n/a | 0.21 | .899 | ||||
| IL1B | HapA5 | n/a | 2.44 | .296 | ||||
| IL1B | HapB1 | n/a | 0.15 | .928 | ||||
| IL1B | HapB7 | n/a | 2.37 | .306 | ||||
| IL1B | HapB9 | n/a | 1.06 | .588 | ||||
| IL1B | HapB11 | n/a | 0.29 | .863 | ||||
| IL1R1 | rs949963 | 96533648 | 2 | .213 | G>A | 2.39 | .302 | A |
| IL1R1 | rs2228139 | 96545511 | 2 | .066 | C>G | 2.29 | .318 | A |
| IL1R1 | rs3917320 | 96556738 | 2 | .068 | A>C | FE | .238 | A |
| IL1R1 | rs2110726 | 96558145 | 2 | .333 | C>T | 1.46 | .483 | A |
| IL1R1 | rs3917332 | 96560387 | 2 | .124 | T>A | 0.83 | .659 | A |
| IL1R2 | rs4141134 | 96370336 | 2 | .401 | T>C | 0.44 | .805 | A |
| IL1R2 | rs11674595 | 96374804 | 2 | .233 | T>C | 0.01 | .998 | A |
| IL1R2 | rs7570441 | 96380807 | 2 | .393 | G>A | 0.60 | .740 | A |
| IL1R2 | HapA1 | n/a | 1.83 | .400 | ||||
| IL1R2 | HapA2 | n/a | 1.55 | .460 | ||||
| IL1R2 | HapA4 | n/a | 0.40 | .818 | ||||
| IL2 | rs1479923 | 119096993 | 4 | .302 | C>T | 2.27 | .322 | A |
| IL2 | rs2069776 | 119098582 | 4 | .244 | T>C | 2.44 | .295 | A |
| IL2 | rs2069772 | 119099739 | 4 | .238 | A>G | 2.43 | .297 | A |
| IL2 | rs2069777 | 119103043 | 4 | .054 | C>T | FE | 1.000 | A |
| IL2 | rs2069763 | 119104088 | 4 | .287 | T>G | 3.95 | .138 | A |
| IL2 | HapA1 | n/a | 1.16 | .560 | ||||
| IL2 | HapA2 | n/a | 2.58 | .275 | ||||
| IL2 | HapA3 | n/a | 2.42 | .299 | ||||
| IL2 | HapA5 | n/a | 2.27 | .322 | ||||
| IL4 | rs2243248 | 127200946 | 5 | .101 | T>G | 2.83 | .243 | A |
| IL4 | rs2243250 | 127201455 | 5 | .260 | C>T | 1.16 | .560 | A |
| IL4 | rs2070874 | 127202011 | 5 | .219 | C>T | 0.01 | .996 | A |
| IL4 | rs2227284 | 127205027 | 5 | .399 | C>A | 0.64 | .725 | A |
| IL4 | rs2227282 | 127205481 | 5 | .401 | C>G | 0.55 | .760 | A |
| IL4 | rs2243263 | 127205601 | 5 | .124 | G>C | FE | .817 | A |
| IL4 | rs2243266 | 127206091 | 5 | .203 | G>A | 0.10 | .950 | A |
| IL4 | rs2243267 | 127206188 | 5 | .205 | G>C | 0.11 | .947 | A |
| IL4 | rs2243274 | 127207134 | 5 | .262 | G>A | 0.58 | .748 | A |
| IL4 | HapA1 | n/a | 0.33 | .847 | ||||
| IL4 | HapA10 | n/a | 0.23 | .891 | ||||
| IL6 | rs4719714 | 22643793 | 7 | .196 | A>T | 1.02 | .600 | A |
| IL6 | rs2069827 | 22648536 | 7 | .071 | G>T | 8.54 | .014 | A |
| IL6 | rs1800796 | 22649326 | 7 | .095 | G>C | 4.71 | .095 | A |
| IL6 | rs1800795 | 22649725 | 7 | .355 | C>G | 0.56 | .755 | A |
| IL6 | rs2069835 | 22650951 | 7 | .066 | T>C | FE | .722 | A |
| IL6 | rs2066992 | 22651329 | 7 | .091 | G>T | 2.97 | .227 | A |
| IL6 | rs2069840 | 22651652 | 7 | .308 | C>G | 3.49 | .175 | A |
| IL6 | rs1554606 | 22651787 | 7 | .405 | T>G | 3.38 | .185 | A |
| IL6 | rs2069845 | 22653229 | 7 | .405 | G>A | 3.38 | .185 | A |
| IL6 | rs2069849 | 22654236 | 7 | .039 | C>T | 7.68 | .021 | A |
| IL6 | rs2069861 | 22654734 | 7 | .083 | C>T | FE | .790 | A |
| IL6 | rs35610689 | 22656903 | 7 | .242 | A>G | FE | .004 | D |
| IL6 | HapA4 | n/a | 3.43 | .180 | ||||
| IL6 | HapA6 | n/a | 0.80 | .670 | ||||
| IL8 | rs4073 | 70417508 | 4 | .498 | T>A | 0.14 | .932 | A |
| IL8 | rs2227306 | 70418539 | 4 | .366 | C>T | 1.86 | .394 | A |
| IL8 | rs2227543 | 70419394 | 4 | .374 | C>T | 2.17 | .337 | A |
| IL8 | HapA1 | n/a | 5.13 | .077 | ||||
| IL8 | HapA3 | n/a | 1.86 | .394 | ||||
| IL8 | HapA4 | n/a | 0.14 | .932 | ||||
| IL10 | rs3024505 | 177638230 | 1 | .138 | C>T | 1.49 | .476 | A |
| IL10 | rs3024498 | 177639855 | 1 | .236 | A>G | 2.40 | .302 | A |
| IL10 | rs3024496 | 177640190 | 1 | .459 | T>C | 0.44 | .802 | A |
| IL10 | rs1878672 | 177642039 | 1 | .452 | G>C | 0.06 | .969 | A |
| IL10 | rs3024492 | 177642438 | 1 | .207 | A>T | 1.96 | .375 | A |
| IL10 | rs1518111 | 177642971 | 1 | .267 | G>A | 2.40 | .302 | A |
| IL10 | rs1518110 | 177643187 | 1 | .267 | G>T | 2.40 | .302 | A |
| IL10 | rs3024491 | 177643372 | 1 | .448 | T>G | 0.17 | .919 | A |
| IL10 | HapA5 | n/a | 0.51 | .775 | ||||
| IL10 | HapA6 | n/a | 2.45 | .294 | ||||
| IL10 | HapA8 | n/a | 1.85 | .397 | ||||
| IL10 | HapA9 | n/a | 1.35 | .510 | ||||
| IL13 | rs1881457 | 127184713 | 5 | .192 | A>C | 2.01 | .366 | A |
| IL13 | rs1800925 | 127185113 | 5 | .227 | C>T | 0.20 | .903 | A |
| IL13 | rs2069743 | 127185579 | 5 | .021 | A>G | FE | .325 | A |
| IL13 | rs1295686 | 127188147 | 5 | .252 | G>A | 0.17 | .920 | A |
| IL13 | rs20541 | 127188268 | 5 | .174 | C>T | 1.27 | .530 | A |
| IL13 | HapA1 | n/a | 0.10 | .950 | ||||
| IL13 | HapA4 | n/a | 1.11 | .574 | ||||
| IL17A | rs4711998 | 51881422 | 6 | .293 | G>A | 0.58 | .749 | A |
| IL17A | rs8193036 | 51881562 | 6 | .255 | T>C | 4.32 | .115 | A |
| IL17A | rs3819024 | 51881855 | 6 | .374 | A>G | 0.63 | .729 | A |
| IL17A | rs2275913 | 51882102 | 6 | .345 | G>A | 2.01 | .366 | A |
| IL17A | rs3804513 | 51884266 | 6 | .027 | A>T | 0.62 | .735 | A |
| IL17A | rs7747909 | 51885318 | 6 | .225 | G>A | 2.49 | .287 | A |
| NFKB1 | rs3774933 | 103645369 | 4 | .444 | T>C | 0.00 | .999 | A |
| NFKB1 | rs170731 | 103667933 | 4 | .397 | T>A | 1.82 | .404 | A |
| NFKB1 | rs17032779 | 103685279 | 4 | .023 | T>C | FE | 1.000 | A |
| NFKB1 | rs230510 | 103695201 | 4 | .366 | T>A | 1.26 | .533 | A |
| NFKB1 | rs230494 | 103706005 | 4 | .477 | A>G | 0.62 | .733 | A |
| NFKB1 | rs4648016 | 103708706 | 4 | .017 | C>T | FE | 1.000 | A |
| NFKB1 | rs4648018 | 103709236 | 4 | .025 | G>C | FE | .149 | A |
| NFKB1 | rs3774956 | 103727564 | 4 | .479 | C>T | 0.52 | .770 | A |
| NFKB1 | rs10489114 | 103730426 | 4 | .025 | A>G | FE | .149 | A |
| NFKB1 | rs4648068 | 103737343 | 4 | .366 | A>G | 0.74 | .692 | A |
| NFKB1 | rs4648095 | 103746914 | 4 | .052 | T>C | FE | .506 | A |
| NFKB1 | rs4648110 | 103752867 | 4 | .205 | T>A | 2.23 | .328 | A |
| NFKB1 | rs4648135 | 103755716 | 4 | .060 | A>G | FE | .120 | A |
| NFKB1 | rs4648141 | 103755947 | 4 | .188 | G>A | 12.29 | .002 | A |
| NFKB1 | rs1609798 | 103756488 | 4 | .337 | C>T | 0.52 | .773 | A |
| NFKB1 | HapA1 | n/a | 1.07 | .586 | ||||
| NFKB1 | HapA9 | n/a | 1.77 | .414 | ||||
| NFKB2 | rs12772374 | 104146901 | 10 | .157 | A>G | 0.25 | .881 | A |
| NFKB2 | rs7897947 | 104147701 | 10 | .229 | T>G | FE | .022 | D |
| NFKB2 | rs11574849 | 104149686 | 10 | .085 | G>A | 0.76 | .684 | A |
| NFKB2 | rs1056890 | 104152760 | 10 | .317 | C>T | 0.38 | .827 | A |
| TNFA | rs2857602 | 31533378 | 6 | .360 | T>C | 2.35 | .309 | A |
| TNFA | rs1800683 | 31540071 | 6 | .388 | G>A | 0.51 | .774 | A |
| TNFA | rs2239704 | 31540141 | 6 | .370 | G>T | 1.95 | .378 | A |
| TNFA | rs2229094 | 31540556 | 6 | .256 | T>C | 0.70 | .706 | A |
| TNFA | rs1041981 | 31540784 | 6 | .388 | C>A | 0.51 | .774 | A |
| TNFA | rs1799964 | 31542308 | 6 | .202 | T>C | 3.52 | .172 | A |
| TNFA | rs1800750 | 31542963 | 6 | .019 | G>A | 0.18 | .913 | A |
| TNFA | rs1800629 | 31543031 | 6 | .157 | G>A | 2.27 | .321 | A |
| TNFA | rs1800610 | 31543827 | 6 | .105 | C>T | 2.57 | .277 | A |
| TNFA | rs3093662 | 31544189 | 6 | .072 | A>G | 1.08 | .584 | A |
| TNFA | HapA1 | n/a | 0.74 | .692 | ||||
| TNFA | HapA5 | n/a | 1.77 | .412 | ||||
| TNFA | HapA8 | n/a | 2.68 | .262 |
Abbreviations: A = Additive model, Chr = chromosome, D = Dominant model, Hap = haplotype, IFNG = interferon gamma, IL = interleukin, MAF – minor allele frequency, n/a = not applicable, NFKB = nuclear factor kappa beta, R = Recessive model, SNP = single nucleotide polymorphism, TNFA = tumor necrosis factor alpha.