Figure 4. Inhibition of sAC, but not tmAC, enhances cerulein (CER)-stimulated zymogen activation and amylase secretion, but not CARB stimulated responses.

Acini were treated with or without the sAC inhibitor KH7 (25–50 µM) for 2 hours or the tmAC inhibitor DDA [25 µM] for 1 hour prior to the addition of either CER [100 nM] or CARB [1 mM]. Cells were assayed after one hour of secretagogue treatment for trypsinogen activation (A,D), chymotrypsinogen activation (B,E) and amylase secretion (C,F). *p<0.05 vs. corresponding CER or CARB treatment alone (n≥3).