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. 2012 Jul 23;7(7):e41355. doi: 10.1371/journal.pone.0041355

Figure 4. TBX2 overexpression in primary human breast tumors is correlated with reduced metastasis-free survival.

Figure 4

Kaplan Meier analysis demonstrates that TBX2 mRNA overexpression is associated with shortened recurrence-free survival (A) in a meta-analysis of six combined published microarray datasets comprising 1107 primary human breast tumors [57], and (B) in an NKI study of 295 women with early-stage invasive breast carcinomas [66]. In both of these datasets, the optimal cut-point value of TBX2 expression was used to divide the samples into high (above median; green) and low (below median; blue) TBX2 expression. A batch correction was performed on the six-study set (see Methods). High TBX2 expression is particularly associated with poor prognosis in estrogen receptor-positive (ER+) breast tumors (right panels). ER status was determined by immunohistochemistry (IHC). P values are indicated.