Table 2.
Select continuous and semiquantitative results (mean ± 95% CIs) and total Mankin HHGS score from the medial tibial plateaus, separated by intervention and/or age group.
| Treatment Group | AC area (μm2) | AC thickness (μm) | SCB area (μm2) | SCB thickness (μm) | CCD area (μm2) | CCD% | #chondr | ACS | Saf-O | Total Mankin HHGS |
|---|---|---|---|---|---|---|---|---|---|---|
| 4.5 month Surgically Induced | ||||||||||
| DMM | 31608 (26557, 36658) | 57.5 (47.1, 67.9) | 88731 (69054, 108409) | 43.3 (35.8, 50.9) | 6747 (4550, 8943) | 20.9 (15.8, 26.0) | 75 (64, 85) | 1.8 (0.4, 3.1) | 8 (6.2, 9.8) | 11.6 (10.9, 12.4) |
| Control | 39607 (34456, 44757) | 56.3 (49.1, 63.4) | 65079 (43111, 87046) | 45.4 (34.5, 56.3) | 2041 (891, 3190) | 5.5 (2.1, 8.7) | 126 (110, 142) | 0.7 (0.0, 1.4) | 4.8 (3.8, 5.8) | 8.5 (6.9, 10.0) |
| P-values | 0.050 | 0.845 | 0.151 | 0.785 | 0.001 | <0.0001 | 0.0001 | 0.315 | 0.016 | 0.004 |
| 5.5 month Surgically Induced | ||||||||||
| DMM | 26925 (18901, 34949) | 31.8 (21.3, 42.2) | 157502 (128522, 186482) | 129.5(104.9, 154.2) | 12150 (9152, 15148) | 48.9 (40.4, 57.5) | 54 (38, 69) | 4.8 (2.6, 7.1) | 8.9 (7.7, 10.1) | 8.9 (6.8, 11.0) |
| Control | 41687 (38294, 45080) | 49.7 (44.6, 54.8) | 112746 (82151, 143342) | 96.0 (69.1, 123.0) | 5330 (3677, 6895) | 12.9 (9.1, 16.7) | 119 (111.4, 126.7) | 1.2 (0.4, 2.0) | 1.7 (0.8, 2.6) | 2.4 (1.5, 3.3) |
| P-values | 0.001 | 0.004 | 0.052 | 0.091 | 0.0004 | <0.0001 | <0.0001 | 0.008 | <0.0001 | <0.0001 |
| Naturally Occurring | ||||||||||
| 16 month | 32313 (23741, 40886) | 39.4 (28.6, 50.2) | 91492 (67355, 115629) | 83.1 (63.5, 102.8) | 4892 (2482, 7300) | 23.6 (6.2, 41.1) | 78 (59, 97) | 3.9 (1.7, 6.1) | 5.7 (4.1, 7.3) | 11.9 (9.1, 14.7) |
| 17 month | 37066 (34093, 40040) | 45.0 (41.3, 48.6) | 111039 (93983, 128094) | 121.4 (81.5, 161.5) | 9090 (6684, 11497) | 26.6 (19.3, 33.8) | 91 (80, 101) | 3.1 (2.1, 4.1) | 2.4 (1.3, 3.4) | 8.0 (6.3, 9.6) |
| 23 month | 37032 (32586, 41478) | 44.1 (38.7, 49.5) | 94910 (83134, 106686) | 87.4 (75.8, 99.0) | 13832 (10657, 17007) | 39.0 (31.0, 47.0) | 70 (59, 80) | 2.5 (1.5, 3.4) | 4.6 (3.3, 5.8) | 10.1 (8.9, 11.4) |
| ANOVA | 0.209 | 0.021 | 0.040 | 0.062 | <0.001 | <0.001 | <0.001 | 0.001 | <0.001 | <0.001 |
AC= articular cartilage, SCB= subchondral bone, CCD= chondrocyte cell death, #chondr= total number of chondrocytes, ACS= articular cartilage structure score, Saf-O=Safranin-O staining score. DMM= destabilized medial meniscus group.